About This Course

The module covers the important principles of genetic segregation and recombination, genotypic and phenotypic ratios generated from crosses of various levels of hybridity in diploid genetic system; the cytological basis of genetic segregation and recombination; probability and statistical testing of Mendelian ratios; various types of intra-allelic (dominance) and inter-allelic (epistatic) gene interactions and the concomitant phenotypic ratios as well as the biochemical/molecular basis underlying gene interactions; influence of internal and external environmental factors on gene expression and effects on genetic ratios; Multiple allelic gene inheritance including genotypic and phenotypic frequencies; patterns of transmission and expression of genes on sex chromosomes; cytoplasmic genes, maternal effect, segregations and inheritance; human genetic study through pedigree analysis, consanguinity and coefficient of inbreeding; polysomic inheritance in auto- and allopolyploids; linkage, detection of linkage and conventional genetic mapping; genetic mapping by tetrad analysis; aberrant segregation of tetrads and gene conversion, and implications about the molecular mechanisms of crossing over; genetic mapping based on mitotic crossing over, human-rodent cell fusion, and parasexual cycle in fungi; complementation mapping and assigning of mutations into allelic and non-allelic groups; linkage and mapping in bacteria(co-transduction, co-transformation, Hfr conjugation); mapping including fine mapping in viruses (bacteriophages).